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The most common side effect with Sustiva (seen in more than 1 patient in 10) is rash. Sustiva is also associated with nervous system symptoms, such as dizziness, headache, somnolence (sleepiness), balance disturbances and impaired concentration, and with psychiatric disorders, including depression, anxiety, insomnia (difficulty sleeping) and abnormal dreams. Taking Sustiva with food may lead to an increase in the frequency of side effects. For a more complete list of side effects reported with Sustiva, see the package leaflet.Depression

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Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease. Sustiva has not been adequately studied in patients with advanced HIV disease, namely in patients with CD4 counts < 50 cells/mm3, or after failure of protease-inhibitor (PI)-containing regimens. Although cross-resistance of efavirenz with PIs has not been documented, there are at present insufficient data on the efficacy of subsequent use of PI-based combination therapy after failure of regimens containing Sustiva.Nervous system

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