Some antibiotic medicines such as rifampicin, erythromycin and clarithromycin drug prescription Third, we did not have the information on other PDE5A inhibitors because neither vardenafil nor tadalafil had been approved by the US Food and Drug Administration in 2000. The observed association between sildenafil use and melanoma might be partly attributed to the later use of vardenafil and tadalafil among recent sildenafil users. A longer clearance time of other PDE5A inhibitors could have augmented the observed HR for sildenafil.12 However, this would not materially jeopardize our study implications for PDE5A inhibitors.
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